Jobbet Thesis work: In vivo CRISPR screening har sparats.


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Thesis work: In vivo CRISPR screening publicerad av AstraZeneca AB



job description.

In vivo CRISPR screening using a customized barcoded library

The Genome Engineering laboratory at the AstraZeneca, Gothenburg, is looking for a Master student to participate in a project to design and use a customized barcoded CRISPR library for in vivo screens.

Are you passionate about the Nobel-prize winning science of genome-editing and its aplications to study human disease. Would you like to apply your expertise to impact the oncology studies in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be of interest to you!


Business area
Genome Engineering, Oncology, Functional Genomics, CRISPR

Main Duties and Responsibilities
Genome-sequencing has catalogued somatic genomic alterations in human diseases. However, identification of these mutations does not reveal their functional importance. CRISPR-Cas9 screenings are used to study the function of genes at large scale. During this master thesis, you will be involved in designing and cloning a customized barcoded guide RNA library for CRISPR-Cas screening. Such library will be used for drug resistance screening for oncology applications. During the project you will be exposed to the state of the art molecular biology techniques such as library cloning, cell culture and next generation sequencing.


Essential Requirements
  • Candidate must be pursuing a master degree in any branch of biological sciences
  • Highly motivated and strong interest in the application of genome engineering in curing the human diseases
  • Knowledge of molecular biology techniques, cell culture and basic understanding of CRISPR-Cas

Desirable Requirements
  • Working knowledge of computer softwares like microsoft office


Randstad Life Sciences is cooperating with AstraZeneca in this recruitment process. We only accept applications through Randstad’s website.

Deadline for application: 2020-10-28, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information: Kerstin Karlsson [ Email address blocked ] or Linnea Öster [ Email address blocked ]



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