Chiesi is looking to recruit a lead clinical pharmacologist/bioinformatician to be part of the Personalised Medicine & Biomarker unit within the R&D, global clinical development at Chiesi.
In this exciting role, you will be responsible for developing, implementing and executing bioanalytical and bioinformatics translational research strategies for assets in early to late stages of clinical development. You will work in close cooperation with the lead functions at clinical programs level (physicians, pharmacologists, statisticians, project managers), preclinical translational scientists, contract research organizations and academic experts to deliver translational science that supports the clinical development of drugs and access of medicine to patients.
If this sounds interesting to you – come join us!
The position is full-time and based in Solna, Sweden. We will evaluate candidates continuously and welcome your application today.
As Lead Clinical Pharmacologist/Bioinformatician you will be a part of the Personalised Medicine & Biomarker unit within the Global Clinical Development organization. You will report to the Head of Personalised Medicine & Biomarker and work closely together with a dynamic team of highly competent, supportive and dedicated colleagues situated in both France and Italy.
Main Responsibilities include:
• Design and execute translational research plans to support clinical development programs by development and implementation of asset-specific strategies (e.g. biological mechanisms of actions, patient segmentations and product differentiation)
• Analyse biomarkers for Chiesi clinical studies by working with relevant functions and CROs
• Integrate and lead hypotheses generation from multi-platform and diverse datasets by employing data science and computational biology approaches
• Develop and apply innovative computational approaches to understand complex disease conditions using different sources, multi-dimensional –omics and clinical data.
• Contribute to data projects to identify biomarkers for indications of interest, through integrated analysis of high-throughput molecular data, real-world data and clinical phenotypes.
• Interface with Chiesi discovery group regarding preclinical understanding of drug mechanism, target engagement and preclinical biomarker readouts
Key Qualifications include:
• MD/PhD or PhD in biological/medical sciences and a minimum of 10+ years’ experience in bioinformatics and/or computational biology
• Knowledge of clinical biomarker discovery, development and analysis, including drug mechanism research, assay development/validation, and state-of-the-art analysis platforms at genetic and protein level.
• Proficiency in analysing of NGS and ‘omics’ data through statistical programming (eg R/Bioconductor)
• Track record of applying bioinformatic analysis (machine learning techniques and network biology) to integrate and analyze omic and clinical data to deliver precision medicine (ideally within respiratory drug development), as well as identify novel patient groups through data mining of large cohort omic data sets.
• Broad understanding of drug discovery and development, especially early and late stage development
• Strong publication record as leading author
We are looking for someone with a strong ability to manage multiple projects in parallel, communicate clearly and effectively, and build open and collaborative relationships. A strong interest in biology, medicine and caring for developing novel therapeutic intervention strategies for patients with unmet disease conditions is essential as well as an ability to liaise with scientists from multiple therapy areas to help define and address biological questions.
If you are ready to bring your experience and skills to this position, we are ready to offer you an exciting and rewarding place of work!
A GLOBAL FAMILY DEDICATED TO PEOPLE AND PATIENTS
In Chiesi our approach as a Benefit Corporation is a way of being as well as a way of thinking. We redefine the way to do our business, to create a positive impact on people, environment and our global Chiesi Community, acting as a force for good.
We are passionate and committed to improving and raising the quality of human life and making meaningful contributions that will have a positive long-lasting impact. Our entrepreneurial thinking, our sustainable and innovative ideas, transformative solutions and our personal chemistry are the key elements that bonds us and make us grow as one cohesive global Chiesi family.
EVERYONE OF US IS DIFFERENT, EVERYONE OF US IS CHIESI
For information about Chiesi, please visit www.chiesi.com and for info about the Global Rare Diseases unit, please visit www.chiesiglobalrarediseases.com.