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Bioanalytical Scientist DMPK publicerad av Hays Specialistrekrytering



Bioanalytical scientist, dmpk, astrazeneca,

Bioanalytical Scientist DMPK

AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. AstraZeneca is proud to offer a unique workplace culture that inspires innovation and collaboration. Co-workers are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

The Arena
Early Research and Development Cardiovascular, Renal and Metabolism (Early CVRM) is one of the main therapeutic research areas within BioPharmaceuticals R&D which deliver candidate drugs into late-stage clinical development. This role in Early CVRM is based in AstraZeneca's world-class vibrant R&D centre, located in Gothenburg, Sweden. Early CVRM DMPK interacts with other functions in supporting CVRM projects all along the value chain, from target selection all the way to market launch and Life cycle management.

Now we are looking for a bioanalytical scientist with good knowledge in the area of quantitative bioanalysis of drugs and drug metabolites to join our team in the DMPK department for a consultant assignment. You will be part of the team focusing on pharmacokinetics, biodistribution and disposition of small molecule, conjugated peptide and nucleotide drug candidates. You will have the opportunity to contribute to the discovery of new life changing medicines for patients and demonstrate and witness what science can do.

Tasks and responsibilities/The role:
You will be responsible for analysing drug candidates and their metabolites in various in vitro and in vivo samples including plasma, tissue, and bile samples as well as sub-cellular fractions.
Your responsibility will include delivering quality in vitro and in vivo bioanalytical data including analysis of drugs, drug candidates and drug metabolites in various in vitro and in vivo samples to support PKPD (Pharmacokinetics and Pharmacodynamics) work in projects from target selection to LCM (life cycle management). The data generated is mainly aimed to provide insight to quantitative pharmacology as well as to right tissue and right exposure aspects, including the fates of drugs and their metabolites.

This laboratory based scientific role includes developing and validating methods to enable delivery of data with the necessary quality and scientific information aligned with the project needs. The role requires interactive, effective communication to provide clear data and guidance to project representatives, act as an example to other scientists, and contribute to the overall team delivery. It will require making judgements about bioanalysis information, developing innovative solutions and applying cross-disciplinary understanding.

Minimum requirements and key factors:

• M.Sc or equivalent degree in a relevant discipline is required (e.g analytical chemistry, biochemistry, biotechnology or pharmacy).

• Good communication skills in English, both verbal and in writing are required.

• Good knowledge of liquid chromatography and mass spectrometry ionization and detection (LC-MS/MS) and bioanalytical work in Drug Discovery & Development.

• Track record of delivering state-of-the-art bioanalysis data to projects in discovery and/or development setting is an advantage.

• Basic understanding of DMPK.

• Understanding of the overall drug discovery and development process.

• Demonstrated ability to work both in team and independently.



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